Highlighted publications
Using germ-free mice, we demonstrate the microbiota is necessary for proper differentiation and repair of the epidermal barrier. These effects are mediated by microbiota signaling through the aryl hydrocarbon receptor in keratinocytes, a xenobiotic receptor also implicated in epidermal differentiation. This work reveals a fundamental mechanism whereby the microbiota regulates skin barrier formation and repair, which has far-reaching implications for the numerous skin disorders characterized by epidermal barrier dysfunction.
Featured article with commentary. Link.
Above artwork is generated by Arwa Abbas.
Publications from 2016 onwards (recent first) can be found below
Publications can also be viewed
2024
The wound microbiota: microbial mechanisms of impaired wound healing and infection
Uberoi A, McCready-Vangi A, Grice EA. Nat Rev Microbiol. 2024 Apr 4.
doi: 10.1038/s41579-024-01035-z. Epub ahead of print. PMID: 38575708.
2023
Variable staphyloxanthin production by Staphylococcus aureus drives strain-dependent effects on diabetic wound-healing outcomes
Campbell AE, McCready-Vangi AR, Uberoi A, Murga-Garrido SM, Lovins VM, White EK, Pan JT, Knight SAB, Morgenstern AR, Bianco C, Planet PJ, Gardner SE, Grice EA. Cell Rep. 2023 Oct 17;42(10):113281. doi: 10.1016/j.celrep.2023.113281.
Harnessing diversity and antagonism within the pig skin microbiota to identify novel mediators of colonization resistance to methicillin-resistant Staphylococcus aureus
Wei M, Flowers L, Knight SAB, Zheng Q, Murga-Garrido S, Uberoi A, Pan JT, Walsh J, Schroeder E, Chu EW, Campbell A, Shin D, Bradley CW, Duran-Struuck R, Grice EA. mSphere. 2023 Jul 5:e0017723. doi: 10.1128/msphere.
Wound microbiota-mediated correction of matrix metalloproteinase expression promotes re-epithelialization of diabetic wounds
White EK, Uberoi A, Pan JTC, Ort JT, Campbell AE, Murga-Garrido SM, Harris JC, Bhanap P, Wei M, Robles NY, Gardner SE, Grice EA.
bioRxiv. 2023.06.30.547263; doi: https://doi.org/10.1101/2023.06.30.547263
Ligand-activation of the aryl hydrocarbon receptor up-regulates epidermal UDP-glucose ceramide glucosyltransferase and glucosylceramides.
Sutter CH, Azim S, Wang A, Bhuju J, Simpson AS, Uberoi A, Grice EA, Sutter TR.
Journal of Investigative Dermatology. 2023 Mar 31:S0022-202X(23)01949-8. doi: 10.1016/j.jid.2023.03.1662. 2022
2022
Cutibacterium acnes evolution: One pore at a time
Flowers L, Campbell A, Uberoi A. Cell Host Microbe. 2022 Feb 9;30(2):144-146. doi: 10.1016/j.chom.2022.01.007.
Staphyloxanthin production by Staphylococcus aureus promotes resistance to oxidative stress to delay diabetic wound healing.
McCready-Vangi A, Campbell AE, Uberoi A, Lovins VM, White, EK, Morgenstern AR, Gardner SE, Grice, E.A. bioRxiv 2022.09.09.507290;
doi: https://doi.org/10.1101/2022.09.09.507290
2021
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor
Uberoi A, Bartow-McKenney C, Zheng Q, Flowers L, Campbell A, Knight SAB, Chan N, Wei M, Lovins V, Bugayev J, Horwinski J, Bradley C, Meyer J, Crumrine D, Sutter CH, Elias P, Mauldin E, Sutter TR, Grice EA.
Cell Host Microbe. 2021 Aug 11;29(8):1235-1248.e8. doi: 10.1016/j.chom.2021.05.011.
The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis
Wei T, Grace M, Uberoi A, Romero-Masters JC, Lee D, Lambert PF, Munger K.
mBio. 2021 Aug 31;12(4):e0227721. doi: 10.1128/mBio.02277-21.
Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining
Yu L, Majerciak V, Xue XY, Uberoi A, Lobanov A, Chen X, Cam M, Hughes SH, Lambert PF, Zheng ZM. PLoS Pathog. 2021 Aug 3;17(8):e1009812. doi: 10.1371/journal.ppat.1009812.
Uberoi, et al. (2021) was selected as a research highlight at the Microbiome Virtual International Forum.
2020
The Wound Microbiome.
Uberoi A, Campbell AE, Grice EA. Book chapter: In Wound Healing, Tissue Repair, and Regeneration in Diabetes.
https://doi.org/10.1016/B978-0-12-816413-6.00012-5
Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.
Wang W, Uberoi A, Spurgeon M, Gronski E, Majerciak V, Lobanov A, Hayes M, Loke A, Zheng ZM, Lambert PF. PLoS Pathog. 2020 Jan 22;16(1):e1008206. doi: 10.1371/journal.ppat.1008206.
The human papillomavirus 16 E5 gene potentiates MmuPV1-Dependent pathogenesis
Torres AD, Spurgeon ME, Bilger A, Blaine-Sauer S, Uberoi A, Buehler D, McGregor SM, Ward-Shaw E, Lambert PF. Virology. 2020 Feb;541:1-12. doi: 10.1016/j.virol.2019.12.002.
2019
Research Techniques Made Simple: Profiling the Skin Microbiota
Grogan MD, Bartow-McKenney C, Flowers L, Knight SAB, Uberoi A, Grice EA. J Invest Dermatol. 2019 Apr;139(4):747-752.e1. doi: 10.1016/j.jid.2019.01.024.
Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy
Kalan LR, Meisel JS, Loesche MA, Horwinski J, Soaita I, Chen X, Uberoi A, Gardner SE, Grice EA. Cell Host Microbe. 2019 May 8;25(5):641-655.e5. doi: 10.1016/j.chom.2019.03.006.
A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract
Spurgeon ME, Uberoi A, McGregor SM, Wei T, Ward-Shaw E, Lambert PF. mBio. 2019 Mar 5;10(2):e00180-19. doi: 10.1128/mBio.00180-19.
2018
Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses
Meyers JM, Grace M, Uberoi A, Lambert PF, Munger K. Front Microbiol. 2018 Mar 8;9:389. doi: 10.3389/fmicb.2018.00389.
Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1)
Uberoi A, Yoshida S, Lambert PF. J Virol Methods. 2018 Mar;253:11-17. doi: 10.1016/j.jviromet.2017.12.002.
2017
Rodent Papillomaviruses
Uberoi A, Lambert PF.
Viruses. 2017 Nov 27;9(12):362. doi: 10.3390/v9120362.
The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues
Xue XY, Majerciak V, Uberoi A, Kim BH, Gotte D, Chen X, Cam M, Lambert PF, Zheng ZM. PLoS Pathog. 2017 Nov 27;13(11):e1006715. doi: 10.1371/journal.ppat.1006715.
Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation
Meyers JM, Uberoi A, Grace M, Lambert PF, Munger K.
PLoS Pathog. 2017 Jan 20;13(1):e1006171. doi: 10.1371/journal.ppat.1006171.
2016
Role of Ultraviolet Radiation in Papillomavirus-Induced Disease
Uberoi A, Yoshida S, Frazer IH, Pitot HC, Lambert PF. PLoS Pathog. 2016 May 31;12(5):e1005664. doi: 10.1371/journal.ppat.1005664.